منابع مشابه
TPBG (trophoblast glycoprotein)
Review on TPBG, with data on DNA/RNA, on the protein encoded and where the gene is implicated.
متن کاملTrophoblast glycoprotein promotes pancreatic ductal adenocarcinoma cell metastasis through Wnt/planar cell polarity signaling.
Trophoblast glycoprotein (TPBG), a 72 kDa glycoprotein was identified using a monoclonal antibody, which specifically binds human trophoblast. The expression of TPBG in normal tissues is limited; however, it is upregulated in numerous types of cancer. When TPBG is expressed at a high level, this usually indicates a poor clinical outcome. In the present study, it was demonstrated that TPBG was m...
متن کامل13-P030 Feedback modulation of Wnt signaling by trophoblast glycoprotein-like
The insulin like growth factors (IGFs) first appeared early in phylogeny about 600 million years ago and have increased in number through gene duplication. In mammals IGFs express in all tissues and are found in many biological fluids. IGF-1 has an important role during central nervous system (CNS) development. IGF-1 promotes differentiation, proliferation and prevents apoptosis of neuronal and...
متن کاملDirect involvement of HERV-W Env glycoprotein in human trophoblast cell fusion and differentiation.
We recently demonstrated that the product of the HERV-W env gene, a retroviral envelope protein also dubbed syncytin, is a highly fusogenic membrane glycoprotein inducing the formation of syncytia on interaction with the type D mammalian retrovirus receptor. In addition, the detection of HERV-W Env protein (Env-W) expression in placental tissue sections led us to propose a role for this fusogen...
متن کاملExpression of HERV-W Env glycoprotein (syncytin) in the extravillous trophoblast of first trimester human placenta.
Although the extravillous trophoblastic invasion has a critical role in human placental development, nothing is known about HERV-W expression in the extravillous phenotype. The aim of the present study was to localize in first trimester placenta the expression of HERV-W Env glycoprotein and its receptor all along the differentiation pathway of the extravillous phenotype. In addition using an in...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2014
ISSN: 1768-3262
DOI: 10.4267/2042/53969